The Effect of Paracetamol in the Treatment of Non-severe Malaria in Children in Guinea-Bissau

• Status: Unknown status
• Trial end date: 2010-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The National Malaria Programme in Guinea-Bissau recommends paracetamol for all children treated for malaria. We, the investigators of the Bandim Health Project, want to evaluate whether this treatment has any effect on:

• the well-being of the child;

• the parasite clearance time; and

• the rate of a re-appearance of parasites during 35 days of follow-up.

Children presenting at Bandim Health Centre with malaria will be treated with chloroquine plus paracetamol or chloroquine plus placebo. Blood samples will be obtained daily for the first 4 days and then once a week until day 35.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Bandim Health Project
• Treatments: Acetaminophen

Criteria

Inclusion Criteria:

• < 15 years of age

• Presenting at Bandim Health Centre

• Symptoms suggestive of malaria

• At least 20 P. falciparum parasites per 200 leukocytes

• Live in Bandim (to enable follow-up)

Exclusion Criteria:

• Severely ill children considered to need the services of a hospital by the doctor in charge

• Previous idiosyncratic reactions to chloroquine or paracetamol