Overview

The Effect of PPI in Preventing Gastroesophageal Reflux Disease of Seafarers

Status:
Not yet recruiting
Trial end date:
2021-11-01
Target enrollment:
0
Participant gender:
All
Summary
In view of the high incidence of GERD among seafarers and its continuing impact on the life quality of seafarers, it is necessary to use preventive treatment. At the same time, because both mental and psychological factors and changes in intestinal flora may play a certain role in the development and treatment of GERD, this project intends to take the seafarers involved in this scientific expedition as the participants to explore the effect of PPI discontinuous therapy in preventing gastroesophageal reflux disease of seafarers, a special occupational group and the changes in the mental and psychological status and intestinal flora of this group of people after PPI therapy.
Phase:
Phase 3
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Fifth Affiliated Hospital, Sun Yat-Sen University
Treatments:
Esomeprazole
Criteria
Inclusion Criteria:

- Agree to the implementation of this research and sign an informed consent form.

Exclusion Criteria:

- PPI drugs were previously used to treat acid-related diseases or conditions (including
peptic ulcer, non-variceal upper gastrointestinal hemorrhage, gastroesophageal reflux
disease, Zollinger-Ellison syndrome, and functional dyspepsia, eradication of
Helicobacter pylori) 2 weeks before enrollment).

- Those having a history of stomach surgery.

- Those who have alarm symptoms (recent weight loss for unknown reasons, such as 5% or
more of the original weight loss in the first half of the year; Progressive dysphagia,
anemia, hematemesis, melena, hematochezia)or physical examination shows abnormalities
such as abdominal rebound pain, masses, etc.).

- Pregnant or lactating women.

- Serious diseases and complications that may interfere with the research, such as
heart, liver, kidney, lung, peripheral or autonomic nervous diseases, diabetes, etc.

- Allergic to PPI drugs.

- Having a history of drug abuse.