The Effect of PPB Using 10, 20 and 30 ml of Lidocaine, Study on Volunteers
Status:
Not yet recruiting
Trial end date:
2025-09-01
Target enrollment:
Participant gender:
Summary
The aim of this study is to evaluate the Popliteal Plexus Block (PPB) effect on motor nerve
branches of the sciatic and femoral nerve, when using different volumes of local anesthetics
for PPB.
The hypothesis is that increasing the volume of anesthetics used for PPB will spread to the
sciatic nerve leading to a reduced muscle strength in the lower leg and decreased nerve
conduction velocity in the nerve to gastrocnemius muscle (the tibial nerve) and the nerve to
anterior tibial muscle (the deep fibular nerve).
The effects will be evaluated by maximum voluntary isometric contraction (MVIC) of the lower
leg muscles and by recordings of the compound muscle action potential (cMAP) of the
gastrocnemius and tibialis anterior muscles - a motor nerve conduction study.
In addition, evaluation of PPBs effect on the femoral nerve is done by MVIC of the quadriceps
femoris muscle, cMAP of the vastus medialis and vastus lateralis muscles and by a sensory
nerve conduction study of the saphenous nerve.
Phase:
Phase 4
Details
Lead Sponsor:
Charlotte Runge
Collaborators:
Danish Society of Anesthesiology and Intensive Care Medicine DASAIM The Danish Rheumatism Association University of Aarhus