Overview

The Effect of PPB Using 10, 20 and 30 ml of Lidocaine, Study on Volunteers

Status:
Not yet recruiting
Trial end date:
2025-09-01
Target enrollment:
0
Participant gender:
All
Summary
The aim of this study is to evaluate the Popliteal Plexus Block (PPB) effect on motor nerve branches of the sciatic and femoral nerve, when using different volumes of local anesthetics for PPB. The hypothesis is that increasing the volume of anesthetics used for PPB will spread to the sciatic nerve leading to a reduced muscle strength in the lower leg and decreased nerve conduction velocity in the nerve to gastrocnemius muscle (the tibial nerve) and the nerve to anterior tibial muscle (the deep fibular nerve). The effects will be evaluated by maximum voluntary isometric contraction (MVIC) of the lower leg muscles and by recordings of the compound muscle action potential (cMAP) of the gastrocnemius and tibialis anterior muscles - a motor nerve conduction study. In addition, evaluation of PPBs effect on the femoral nerve is done by MVIC of the quadriceps femoris muscle, cMAP of the vastus medialis and vastus lateralis muscles and by a sensory nerve conduction study of the saphenous nerve.
Phase:
Phase 4
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Charlotte Runge
Collaborators:
Danish Society of Anesthesiology and Intensive Care Medicine DASAIM
The Danish Rheumatism Association
University of Aarhus
Treatments:
Lidocaine
Criteria
Inclusion Criteria:

- ASA 1-2

- Ability to give their written informed consent to participating in the study after
having fully understood the contents of the study

Exclusion Criteria:

- Subjects who cannot cooperate with the study.

- Subjects who cannot understand or speak Danish.

- Subjects with allergy to the medicines used in the study.

- Subjects suffering from alcohol and/or drug abuse - based on the investigator's
opinion.

- Pathology or previous surgery to the lower limb.

- Intake of any analgesics 24 hours prior to baseline measurements.

- BMI > 30

- Pregnancy status, provided by the volunteer.