The Effect of Ondansetron on Spinal Anesthesia in Caesarean Section

• Status: Recruiting
• Trial end date: 2022-05-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to compare the administration of two different doses of ondansetron to placebo to prevent hypotension and bradycardia following spinal anaesthesia. Apart from haemodynamic parameters (blood pressure and heart rate),characters of the spinal blockage (time of onset and regression) will be recorded too.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Aretaieion University Hospital
• Collaborator: University of Athens
• Treatments: Anesthetics; Ondansetron

Criteria

Inclusion Criteria:

• Physical status according to American Society of Anesthesiologists (ASA) I-II

• Singleton pregnant women in full term pregnancy

• Patients scheduled for cesarean section

• Height 158cm-170cm

Exclusion Criteria:

• patient's own refusal

• contraindications to spinal anesthesia (coagulation disorders, inflammation at the puncture site, allergy to local anesthetics)

• ondansetron allergy

• body mass index> 33kg / m^2

• height <158cm, or> 170cm

• hypertensive disorders of pregnancy

• cardiovascular disease

• receiving selective serotonin reuptake inhibitors (SSRI's) or treatment for migraine

• placenta previa.