The Effect of Nitroglycerine on Microcirculatory Abnormalities During Sepsis

• Status: Completed
• Trial end date: 2008-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the effect of nitro-glycerine on the microcirculation (smallest vessel type) in patients with severe sepsis and septic shock.

Nitro-glycerine is a well known medicine in cardiology and is used to improve circulation. In this ICU the investigators use nitro-glycerine to improve the organ perfusion; but it's no common therapy in the rest of the world. The investigators now compare nitro-glycerine and placebo by looking to the sublingual microcirculation by a small camera (SDF imaging).

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Medical Centre Leeuwarden
• Treatments: Nitroglycerin

Criteria

Inclusion Criteria:

• Severe sepsis

• Proven infection

• Informed consent

Exclusion Criteria:

• Age < 18 years

• Pregnancy

• Use of nitroglycerine within 24 hours prior to ICU admittance

• Necessity to use nitroglycerine iv for instable angina