The Effect of Nimodipine on the Postoperative Cognitive Dysfunction
Status:
Terminated
Trial end date:
2017-12-01
Target enrollment:
Participant gender:
Summary
The calcium channel blocker nimodipine dilates cerebral blood vessels and can pass through
the blood-brain barrier, providing neuroprotective effects by selectively improving cerebral
blood flow and inhibiting neuronal necrosis and apoptosis. Nimodipine significantly inhibited
the production of tumor necrosis factor TNF-α and interleukin IL-1β, and also of nitric oxide
and prostaglandin E2 from lipopolysaccharide-stimulated microglia. Abnormal cytokine networks
are important in the development of nerve cell damage that leads to cognitive impairment.