The Effect of Nicotine Delivery Rate on Reinforcement
Status:
Completed
Trial end date:
2018-01-29
Target enrollment:
Participant gender:
Summary
The dose-effect curve to estimate a threshold delivery rate for reinforcement. The project
addresses the FDA Center for Tobacco Products (CTP) interest #1: Nicotine dependence
threshold among youth and adults and impact of nicotine reduction on tobacco product use
behavior (e.g., topography, compensation, switching, multiple use, initiation, cessation and
relapse). IV nicotine, in contrast to ECs, can deliver precise, reproducible dosing, which is
necessary for accurately assessing dose-response and threshold effects. The estimated
threshold for reinforcement will establish a benchmark for evaluating the addictive potential
of ECs and other inhaled nicotine products.