The Effect of Nebulization of Alkaline Solution on Treating XDRAB Pneumonia With C/S Plus Minocycline
Status:
Unknown status
Trial end date:
2015-04-01
Target enrollment:
Participant gender:
Summary
The mortality of pneumonia with extensively drug resistant Acinetobacter baumannii (XDRAB) is
still high, even if these patients received certain strong anti-infection treatment such us
the combination of cefoperazone-sulbactam (C/S) and minocycline. Health airway lining fluid
is mildly alkaline but airway acidification usually appears for the infection of XDRAB. The
hypothesis is offered that the biologic activity of XDRAB might be inhibited if the
circumstance including pH is changed. In the vitro study we observed that the inhibit effect
of antibiotics on XDRAB growth was improved significantly by alkaline solution within the
scope of physiology. So the aim of this clinical study is to explore the effects of
nebulization of alkaline Solution on C/S plus minocycline on the pneumonia with XDRAB.