Overview

The Effect of Nebivolol on Insulin Sensitivity

Status:
Completed
Trial end date:
2009-01-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to conduct a randomised trial to compare the insulin sensitivity, 24 hour blood pressure profile, and tolerability of nebivolol plus a thiazide-like diuretic versus atenolol plus a thiazide-like diuretic.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Imperial College London
Collaborator:
Foundation for Circulatory Health
Treatments:
Atenolol
Insulin
Nebivolol
Criteria
Inclusion Criteria:

- Males or females aged 18 or above

- Blood pressure that meets any of the three following criteria:

- BP should be <140/85 mmHg on a maximum of two anti-hypertensive drugs

Exclusion Criteria:

- contraindications to beta-blockade

- contraindications to thiazide use

- if there was a history of asthma, diabetes, heart failure, bradycardia, atrial
fibrillation, AV conduction disturbances

- concurrent treatment with verapamil & dilitiazem

- childbearing women

- compelling indication for treatment with a beta blocker

- any condition that will interfere with the treatment or the patient's ability to
complete the study