The Effect of Mitomycin C on Corneal Haze and Scarring After Corneal Crosslinking in Keratoconus Patients
Status:
Recruiting
Trial end date:
2023-02-01
Target enrollment:
Participant gender:
Summary
Corneal crosslinking (Crosslinking, CXL) is a treatment offered for the stabilization of
early corneal ectatic disorders such as keratoconus. Although CXL is an excellent treatment
option to stabilize early ectatic corneas, complications include corneal haze, sterile
infiltrate, endothelial cell toxicity, treatment failure and stromal scarring. Corneal haze
is a common finding in almost all CXL patients and may decrease visual quality. The effect of
0.02% mitomycin C (MMC) for 2 minutes on corneal haze and scarring in refractive surgery is
well established in the literature with many clinical studies confirming its effectiveness.
Although the pattern of corneal haze after CXL appears to be different from the haze pattern
seen following refractive procedures, both processes are thought to be caused by an
inflammatory response.
The investigators postulate that MMC can reduce post-CXL haze and scars when using the
optimal concentration and duration of exposure.