The Effect of Metformin on Different Hormones in PCOS Patients
Status:
Completed
Trial end date:
2015-09-01
Target enrollment:
Participant gender:
Summary
Forty eight PCOS patients were included . The diagnosis of PCOS was made based on the three
criteria set by the Rotterdam Consensus meeting definition of PCOS (ESHRE, ASRM, 2004). The
criteria were as follows:
1. history of chronic anovulation defined as cycle length > 35 days, or less than 9 cycles
per year or amenorrhoea (cycle length > 12wks),
2. infertility with hirsutism or acne or elevation of one or more of serum androgen levels
3. ultrasonographic findings of polycystic ovaries ( increased ovarian volume, more than
eight follicles in an ovary ranging from 2-10mm).
the studied subjects were to receive metformin 850 mg twice daily over a period of 6 months.
Blood samples were collected at the start of the study, before receiving metformin, where
baseline serum insulin (fasting and 2 hr postprandial), sex hormone binding globulin (SHBG) ,
total and free testosterone, Dihydroepiandrostenedione sulphate (DHEAS) and Antimullerian
Hormone (AMH) were obtained before starting metformin. Blood samples were collected at 3 and
6 months respectively of metformin treatment , to asses its effect on serum levels of the
previously mentioned hormonal parameters.