The Effect of Memantine on Brain Structure and Chemistry in Alzheimer's Disease Patients
Status:
Completed
Trial end date:
2010-02-01
Target enrollment:
Participant gender:
Summary
The aim of the proposed study is to determine if the NMDA receptor antagonist memantine has a
neuroprotective effect on magnetic resonance spectroscopic imaging (MRS) measures of brain
NAA and magnetic resonance imaging (MRI) volumetric measures of hippocampal volume. In
secondary analyses, we will determine if measures of clinical stabilization produced by
memantine in the treatment of Alzheimer's disease (AD) parallels stabilization of MRS
measures of brain NAA and MRI volumetric measures of hippocampal volume.
Phase:
Phase 3
Details
Lead Sponsor:
Stanford University
Collaborators:
Forest Laboratories Palo Alto Veterans Institute for Research