The Effect of Melatonin on Postoperative Pain Reduction After Orthognathic Surgery
Status:
Recruiting
Trial end date:
2024-09-01
Target enrollment:
Participant gender:
Summary
Orthognathic surgery is a procedure performed to correct dentofacial deformities. It involves
osteotomy at the facial skeleton. Considerable pain is expected in the early recovery period.
Melatonin is a hormone that is produced naturally by the body. Synthetic Melatonin is
available over the counter for the management of sleeping disorder and jetlag. Clinically,
Melatonin can also be used to reduce pain and analgesic consumption in patients undergoing
surgery.
Dexamethasone is a type of steroid. It can suppress the inflammatory response. It is an
anti-inflammatory, anti-allergic drug. It is commonly used in head and neck and oral surgery
for its anti-inflammatory effect to reduce swelling.
This study aims evaluate the efficacy of oral melatonin in the pain reduction following
orthognathic surgery.
This is a double-blinded randomized controlled trial. We will recruit 87 patients who are
scheduled for double-jaw orthognathic surgery to participate in this three-year study. The
study lasts for 2 weeks. Participant will be randomly allocated by computer to one of the
three groups. (1) Group D will receive dexamethasone only; (2) Group M will receive melatonin
only; and (3) Group DM both melatonin and dexamethasone.
Postoperative pain level and perioperative plasma levels of inflammatory markers and
anti-oxidizing enzymes will be recorded and compared among the study groups.