The Effect of Low-dose Atropine on Sympathetic Blockade in Spinal Cesarean Section Patients
Status:
Not yet recruiting
Trial end date:
2023-12-10
Target enrollment:
Participant gender:
Summary
The most common side effect in cesarean section surgeries performed under spinal anesthesia
is hypotension, which is seen in over 80% and can cause significant morbidity for the mother
and fetus. This side effect results from the sympathetic blocking effect, which also causes
bradycardia.
A combined approach is supported in the prevention and treatment of hypotension, which
recommends adequate fluid support, low-dose spinal anesthesia, and appropriate vasopressor
(such as ephedrine, and phenylephrine) and, if bradycardia develops, the use of atropine as a
parasympatholytic agent.
In this study, we planned to investigate the possible benefits of preemptive administration
of atropine, the dose of which is calculated in proportion to the patient's weight, as soon
as a 10% decrease in heart rate is detected, in order to balance the sympathetic blockade due
to spinal anesthesia in cesarean section operations.