The Effect of Low Dose Ketamine on Narcotic Consumption in Patients Undergoing Laparoscopic Cholecystectomy
Status:
Completed
Trial end date:
2013-11-30
Target enrollment:
Participant gender:
Summary
The study was a double-blind randomized controlled trial, carried out at the Department of
Anaesthesia, Aga Khan University Hospital. Sample size was calculated to be 86 with 80% power
at 5% significance level assuming a 30% difference in the mean narcotic consumption in the
test group using NCSS~Pass (version, 11.04)(Reference for calculation). Patients were divided
into two groups of 43 each, one received saline and the other received 0.5mg/kg ketamine
before wound closure. Randomization was done with the help of sealed envelope method. All
patients were observed in the recovery room for one hour to see the magnitude of
post-operative pain using Visual Analogue Scale. The amount of narcotic consumption was
noted. Data were analyzed using SPSS version 19.