The Effect of Local Application of Tranexamic Acid Versus Placebo on Postoperative Complications in Plastic Surgery
Status:
RECRUITING
Trial end date:
2029-12-31
Target enrollment:
Participant gender:
Summary
Study objective:
This is a study to investigate whether applying the drug tranexamic acid (TXA) onto a surgical wound surface may affect the incidence of surgical complications such as re-bleeding needing intervention, wound complications such as infection, wound rupture or seroma, or if it may increase the risk of blood clots.
Eligible patients:
Patients undergoing plastic surgical procedures with wounds that would normally receive application of TXA to reduce bleeding after surgery.
Study intervention:
Participants will receive a single local application of study drug onto their wound surfaces at the end of surgery. Study drug will be identical looking ampoules which contain either TXA or placebo (saline). Neither participants nor study personnel will know the contents of the ampoules.
Phase:
PHASE4
Details
Lead Sponsor:
St. Olavs Hospital
Collaborators:
Bodø sykehus Haraldsplass Deaconess Hospital Haukeland University Hospital Helse Stavanger HF Helsinki University Central Hospital Molde Hospital Oslo University Hospital Smerud Medical Research International AS Sykehuset Asker og Baerum Sykehuset Innlandet HF Sykehuset Telemark University Hospital of North Norway