Overview

The Effect of Loading Dose of Magnesium Sulfate on Uterine, Umbilical, and Fetal Middle Cerebral Arteries Doppler, Biophysical Profile, CTG, Maternal Vital Signs in Women With Severe Preeclampsia

Status:
Unknown status
Trial end date:
2019-12-01
Target enrollment:
0
Participant gender:
Female
Summary
100 women with severe preeclanpsia received Magnesium sulfate 6 grams intravenous over 20 minutes as a loading dose. Resistance index [RI], pulsatility index [PI] and systolic/diastolic [S/D] ratio of the umbilical artery, uterine aryery and fetal middle cerebral artery before and repeated 20 minutes after intravenous administration of 6 grams of magnesium sulphate (loading dose) over 20 minutes . fetal breathing movements and fetal gross movements are counted within 20 minutes, before and after intravenous administration of 6 grams of magnesium sulphate (loading dose) over 20 minutes
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Cairo University
Treatments:
Magnesium Sulfate
Criteria
Inclusion Criteria:

- Singleton pregnancy.

- Primigravida or Multigravida.

- Pregnant females ≥ 37 weeks of gestation.

- Diagnosed as severe preeclampsia by the following criteria:

- Sustained systolic blood pressure of ≥160 mmHg or a sustained diastolic blood
pressure of ≥ 110 mmHg.

- Proteinuria measured as +1 or more by dipstick or 24 hours urine collection with
proteinuria ≥ 0.3 grams.

- Oliguria or creatinine > 1.1 mg%.

- Laboratory findings characteristic of HELLP syndrome.

- Symptoms suggestive of severe preeclampsia ; severe headache, blurring of vision,
epigastric pain.

Exclusion Criteria:

- Multifetal pregnancy.

- History of epilepsy.

- Patients with diabetes.

- Patients with renal disease.

- Fetuses with congenital anomalies.

- Patients receiving anticoagulants e.g. heparin (unfractionated or low molecular
weight).

- Patients with severe IUGR.

- Patients with accidental hemorrhage.