The Effect of Levcromakalim Infusion on the Cranial Arteries Over Several Hours Using a High Resolution MRA Technique in a Randomized, Double-blind Placebo-controlled Design in Healthy Volunteers.

• Status: Completed
• Trial end date: 2018-08-15
• Target enrollment: 0
• Participant gender: All

Summary

Healthy participants vill randomly be allocated in a 2:1 order to receive 1 mg levcromakalim or placebo (isotonic saline) for 20 min.

The investigator here examine the effect of levcromakalim infusion on the MMA and the MCA circumference over several hours using a high resolution MRA technique in a randomized, double-blind placebo-controlled design in healthy volunteers. The investigator hypothesized that levcromakalim induces dilatation of cranial arteries.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Danish Headache Center
• Treatments: Cromakalim

Criteria

Inclusion Criteria:

• Healthy volunteers of both sexes.

• 18-60 years.

• 50-100 kg.

• Women of childbearing potential must use adequate contraception.

Exclusion Criteria:

• A history of serious somatic disease

• Migraine or any other type of headache (except episodic tension-type headache less than once a month)

• Daily intake of any medication except contraceptives

• Contraindications for MRI scan.