The Effect of Lanthanum Carbonate on Fibroblast Growth Factor 23

• Status: Unknown status
• Trial end date: 2014-07-01
• Target enrollment: 0
• Participant gender: All

Summary

To compare the effect of lanthanum carbonate with calcium carbonate on serum FGF23 levels in hemodialysis patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Camillians Saint Mary's Hospital Luodong
• Treatments: Calcium; Calcium Carbonate; Calcium, Dietary; Mitogens

Criteria

Inclusion Criteria:

• Age > 18 years old

• Chronic renal failure on maintenance hemodialysis 3 times a week for at least 3 months Serum calcium:8-10.5 mg/dL

• Serum phosphate:3.5-6 mg/dL(before washout period)

• Serum phosphate ≧6 mg/dL after washout period

• Serum i-PTH: 150-600 pg/mL

Exclusion Criteria:

• Diabetes mellitus

• Post parathyroidectomy

• Life expectancy< 6 months

• Liver disease(hepatitis B,C or liver dysfunction)

• Severe gastrointestinal disorders or other severe comorbidity

• Poor compliance

• Intolerance to lanthanum or calcium carbonate

• Active infection

• Malnutrition(serum albumin<3 g/dL or clinical assessment)

• Kt/V< 1.2 (inadequate dialysis)

• Serum phosphate>7.5 mg/dL after washout period