The Effect of LSD on Neural Synchrony, Prosocial Behavior, and Relationship Quality

• Status: Recruiting
• Trial end date: 2024-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this study is to assess the effects of LSD on neural synchrony, prosocial behavior, and relationship quality in healthy romantic couples.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Maastricht University
• Treatments: Ethanol; Lysergic Acid Diethylamide

Criteria

Inclusion Criteria:

• Written Informed Consent

• Understanding the procedures and the risks associated with the study.

• Age between 18 and 35 years old.

• Being in a steady relationship for at least 6 months.

• Proficient knowledge of the English language

• Previous experience with at least one psychedelic drug (psilocybin, LSD, mescaline, Ayahuasca, DMT, 5-MeO-DMT), but not within the past 3 months

• Absence of any major medical condition as determined by medical examination and laboratory analysis

• Absence of any major psychological condition as determined by medical examination

• Free from psychotropic medication

• Participants must be willing to refrain from taking illicit psychoactive substances during the study.

• Participants must be willing to drink only alcohol-free liquids and no coffee, black or green tea, or energy drink after midnight of the evening before the study session, as well as during the study day.

• Participants must be willing not to drive a traffic vehicle or to operate machines within 24 h after substance administration.

• Normal weight, body mass index (weight/height2) between 18 and 28 kg/m2

Exclusion Criteria:

• History of drug addiction (determined by the medical questionnaire, drug questionnaire and medical examination)

• Previous experience of serious side effects to psychedelic drugs (anxiety or panic attacks)

• Pregnancy or lactation

• Hypertension (diastolic > 90 mmHg; systolic > 140 mmHg)

• Current or history of psychiatric disorder (determined by the medical questionnaire and medical examination)

• Psychotic disorder in first-degree relatives

• Any chronic or acute medical condition

• History of cardiac dysfunctions (arrhythmia, ischemic heart disease,…)

• For women: no use of a reliable contraceptive

• Tobacco smoking (>20 per day)

• Excessive drinking (>20 alcoholic consumptions per week)

• Experience with a full dose of a psychedelic within the last three months

• Current use of SSRI medication