Overview

The Effect of LH Supplementation on the Endometrial Gene Expression Profile During Ovarian Stimulation in Poor Ovarian Responders

Status:
Not yet recruiting

Trial end date:
2024-08-01

Target enrollment:

Participant gender:

Summary

This is a prospective randomized open-label cross-over study. Poor responder patients will undergo two ovarian stimulation cycles. One with recombinant follicle stimulation hormone (FSH), and an other stimulation with recombinant FSH and recombinant luteinizing hormone (LH). In both groups, a freeze-all strategy will be applied and an endometrial biopsy will be taken 7 days after final oocyte maturation trigger. Endometrial gene expression analysis will be performed on both biopsies. After completion of both treatment cycles, a frozen embryo transfer of a single embryo will be performed.

Phase:

Phase 4

Details

Lead Sponsor:

CRG UZ Brussel

Collaborator:

Merck Sharp & Dohme LLC

Treatments:

Follicle Stimulating Hormone