The Effect of Ketamine on Production of Inflammatory Markers in Post Operative Patients in Mulago Hospital

• Status: Unknown status
• Trial end date: 2011-06-01
• Target enrollment: 0
• Participant gender: All

Summary

. Null Hypothesis: Giving low doze ketamine (0.5mg/kg) given preoperatively to adult patients undergoing elective surgery, in Mulago hospital, will not have a reduction effect on the levels of IL-6 & IL-1β pro inflammatory markers by 48 hours.

. Alternate Hypothesis: Giving low doze ketamine (0.5mg/kg) given preoperatively to adult patients undergoing elective surgery, in Mulago hospital, will have a reduction effect on the levels of IL-6 & IL-1β pro inflammatory markers by 48 hours.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Makerere University
• Treatments: Ketamine

Criteria

Inclusion Criteria:

• Consented patients due for elective surgery

• Adult patients 18- 70 year old

• ASA I- ASA II scoring patients, who are normal patients or those with mild systemic illness

Exclusion Criteria:

• Emergency cases that will already have high levels of inflammatory markers secreted in their system by incision time e.g. road traffic accidents

• Patients with chronic / severe hypertension

• Febrile Patients (T >38°C)

• Persistently raised blood pressures above 140/90 for 2 consistent readings 15 minutes apart

• Patients with pheochromocytoma

• Spinal and local infiltration anaesthesia cases

• Neuro surgery patients whom Ketamine is contra indicated

• Epilepsy patients

• ASA IIIE and above

• Patients receiving Aspirin prophylaxis

• Chronic inflammatory disease states such as hyperparathyroidism