The Effect of Ketamine on Interleukin-6 Synthesis in Hepatic Resections Requiring Temporary Porto-arterial Occlusion

• Status: Completed
• Trial end date: 2008-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether ketamine is effective to inhibit interleukin 6 synthesis in hepatic resections requiring temporary porto-arterial occlusion.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hospital Italiano de Buenos Aires
• Treatments: Ketamine

Criteria

Inclusion Criteria:

• Age: 21 or older

• Planned liver resection with Pringle maneuver lasting 30-60 minutes

Exclusion Criteria:

• Chronic illness requiring corticosteroids

• Cirrhosis

• Hemodynamic instability prior to surgery

• Diabetes

• Sepsis

• Surgical interventions or chemotherapy treatments within the past 30 days

• Pregnancy

• Illnesses that could potentially affect the hepatic circulation

• Arterial hypertension

• Ocular hypertension

• Allergy to ketamine

• Preoperative portal embolization

• Radiofrequency ablation

• Patients requiring emergency surgeries