The Effect of Ketamine on Immune Function and Prognosis in Patients Undergoing Colorectal Cancer Resection

• Status: Unknown status
• Trial end date: 2020-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Systemic inflammation caused by surgery may aggravate immunosuppression in immunocompromised cancer patients. The natural killer (NK) cell is a critical part of anti-tumor immunity. ketamine, a N-methyl-D-asparate receptor antangonist, has anti-inflammatory activity and opioid-sparing effect. This study investigate the effect of intraopertaive ketamine administration on immune function in patients undergoing laparoscopic colorectal cancer resection.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yonsei University
• Treatments: Ketamine

Criteria

Inclusion Criteria:

• patient between 20 and 80 of age with ASA physical status Ⅰ-Ⅲ

• patient scheduled for laparoscopic colorectal cancer resection

Exclusion Criteria:

• ASA physical status Ⅳ

• severe hepatorenal disease

• heart failure

• infection

• increased intracranial pressure, seizure

• preoperative chemotherapy

• immune or endocrine disease

• metastasis to other organ

• problem with communication

• pregnancy

• body mass index > 35 kg/m2