The Effect of Iron Deficiency Anemia During Pregnancy
Status:
Completed
Trial end date:
2017-12-01
Target enrollment:
Participant gender:
Summary
Iron deficiency anemia during pregnancy is a significant worldwide health problem, affecting
22% of pregnant women in industrialized countries and 52% in non-industrialized countries.
Iron deficiency anemia during pregnancy is associated with increased maternal as well as
fetal morbidity, including prematurity, low birth-weight and perinatal and infant loss.
Therefore, routine iron supplementation during the second half of pregnancy has been
recommended once daily. Others, however, support a selective iron supplementation only for
women with iron deficiency anemia, in order to avoid the increased risk of haemoconcentration
associated with routine iron supplementation. Unfortunately, compliance to either
iron-supplementation programs, especially among pregnant women, is poor, due in part to the
side effects associated with these preparations.
Currently, there are many iron preparations available containing different types of iron
salts, including ferrous sulfate, ferrous fumarate, ferrous ascorbate but common adverse drug
reactions found with these preparations are mainly gastrointestinal intolerance like nausea,
vomiting, constipation, diarrhea, abdominal pain, while ferrous bis-glycinate (fully reacted
chelated amino acid form of iron) rarely make complication.
Product resulting from the reaction of a metal ion from a soluble salt with amino acids to
form coordinate covalent bonds, the resulting molecule is called as chelate and chemical
bonding process is called chelation. Ferrous bis-glycinate is highly stable and totally
nutritionally functional chelate it is an amino acid fully reacted chelate which is formed by
the binding of two molecules of glycine to one Fe2+ atom.