The Effect of Intrawound Vancomycin Powder in Spine Surgery
Status:
Recruiting
Trial end date:
2022-07-01
Target enrollment:
Participant gender:
Summary
Problem: Postoperative wound infection following various spinal surgeries is a serious
complication. The incidence of post-surgical wounds in spine surgery is high, and various
researchers have reported different infection rates. In addition, increased healthcare costs,
prolonged lengths of stay in hospital, and reduced quality of life as a result of surgical
site infections (SSI) are also major concerns. Several methods for avoiding SSI, such as
betadine irrigation, vacuum-assisted closure, and intra-wound vancomycin powder, have been
used to reduce the rate of wound infection in spine surgery. Use of local vancomycin has been
popular because of its protective effects and lower cost. According to some reports,
prophylactic administration of intra-wound vancomycin powder before wound closure is an
effective method for decreasing postoperative wound infection rates; however, other studies
have revealed a non-significant effect of intra-wound vancomycin use for decreasing the
postsurgical wound infection rate.
Solution: Therefore, the investigators will prospectively randomize all various types of
spinal surgeries to patients who will receive intrawound vancomycin powder and control group
who will not receive the powder and to see it's effect in reducing the post-surgical
infection.