Overview

The Effect of Intravenous Lidocaine on THBS2 and Angiogenic Factors Expression in Women Undergoing Cervical Cancer Surgery

Status:
Not yet recruiting
Trial end date:
2024-12-01
Target enrollment:
0
Participant gender:
Female
Summary
The purpose of this study is to investigate the efficacy of intravenous lidocaine on THBS2, MMPs and VEGF-C in serum in cervical cancer patients undergoing radical hysterectomy under general anesthesia.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
General Hospital of Ningxia Medical University
Treatments:
Lidocaine
Criteria
Inclusion Criteria:

- Patients were scheduled by following cervical cancer surgery under general anesthesia

- Aged 18-65 years

- ASA physical status Ⅱ-Ⅲ

Exclusion Criteria:

- Severe heart, pulmonary, hepatic and renal insufficiency

- History of neurological diseases

- Autoimmune disorders

- Antiarrhythmic drugs (amiodarone, verapamil, propafenone)

- Patients' decision to withdraw anytime from the study, and refusal to participate
before surgery and at postoperative follow-up

- Allergy to one of the used medications

- Psychiatric illness, psychological disorder, and drug or alcohol abuse

- Unwillingness to comply with the protocol or procedures

- Preoperative treatment of chemotherapy, radiation, NSAID and hormonal therapy

- History of anesthesia and surgery in two weeks

- Coexisting other cancers and intraoperative presence of liver metastasis

- Perioperative treatment of blood transfusion