The Effect of Intranasal Insulin Administration on Cognitive Function After Cardiac Surgery.
Status:
Not yet recruiting
Trial end date:
2023-04-01
Target enrollment:
Participant gender:
Summary
Decline in cognitive function after surgery occurs most commonly in older patients and
patients undergoing major surgeries, such as heart surgery. Postoperative Cognitive
Dysfunction (POCD) may last a prolonged period of time while Postoperative Delirium (POD) is
a more acute disturbance in attention, awareness and cognition. The cause of POCD and POD are
not fully understood, however some of the pathophysiology of POCD is similar to that of
Alzheimer's disease (AD).
Insulin given intravenously during heart surgery has been shown to preserve short and
long-term memory function after the operation. Clinical trials further demonstrated that
insulin given via the nose (intranasal) improves memory performance of patients with AD or
cognitive impairment suggests that intranasal insulin also could be a therapeutic option for
POCD and POD.
This study is designed to examine the effect intranasal insulin on POCD and POD. The goal is
to investigate whether administration of intranasal insulin during and after heart surgery
improves cognitive function postoperatively.
Phase:
N/A
Details
Lead Sponsor:
McGill University Health Center McGill University Health Centre/Research Institute of the McGill University Health Centre