The Effect of Influenza Vaccination on the Systemic Inflammatory Response and Myocardial Protection in Patients Undergoing Cardiac Surgery: a Randomized Controlled Trial

• Status: Completed
• Trial end date: 2018-12-25
• Target enrollment: 0
• Participant gender: All

Summary

To assess the impact of influenza vaccination on the overall systemic inflammatory response in patients undergoing cardiac surgery and investigate functional and clinical outcomes in vaccinated patients postoperatively.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Health Sciences North Research Institute
• Treatments: Vaccines

Criteria

Inclusion Criteria:

• Subjects who the investigator believes can and will comply with the requirements of the protocol (i.e. return for follow-up visits, and able to converse with study personnel)

• Age 18 years or older

• Undergoing major cardiac surgery using cardiopulmonary bypass

Exclusion Criteria:

• Have not received influenza vaccination in the past or cannot be vaccinated due to previous severe reaction to influenza vaccine, egg, latex, or thimerosol allergies, or refusal of vaccination

• Participant has received a community available influenza vaccine within <6 months

• History of Guillain-Barré syndrome

• Immunosuppressive disorders or medications (including oral prednisone >10 mg daily, recent chemotherapy treatment)

• Emergency cases as determined by the investigator or physician