The Effect of Imipramine on Early Information Processing

• Status: Completed
• Trial end date: 2006-01-01
• Target enrollment: 0
• Participant gender: Male

Summary

We wanted to compare the relation of two different psychophysiological paradigms (PrePulse Inhibition of the startle response = PPI and P50 suppression) to each other. Additionally, we wanted to test the effect of the combined serotonin- and noradrenaline re-uptake inhibitor, imipramine, on these measures. The primary hypothesis was that PPI and P50 gating would not correlate with each other at baseline. The secondary hypothesis was that increased noradrenergic and serotonergic activity would disrupt PPI as well as P50 gating.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Birte Glenthoj
• Collaborators: Glostrup University Hospital, Copenhagen; Lundbeck Foundation; The Danish Medical Research Council; University of Copenhagen
• Treatments: Imipramine

Criteria

Inclusion Criteria:

• Male subjects

• Good Physical and Mental Health meeting criteria "never mentally ill", which will be evaluated with a medical history checklist, ECG

• Non smokers

Exclusion Criteria:

• Current use of any medication

• Any subject who has received any investigational medication within 30 days prior to the start of this study

• History of neurologic illness

• History of psychiatric illness in first-degree relatives, evaluated with DSM-IV criteria

• History of alcohol and drug abuse. Positive urine screening for amphetamine, cocaine, cannabis, or ecstasy.