The Effect of Imipramine on Early Information Processing
Status:
Completed
Trial end date:
2006-01-01
Target enrollment:
Participant gender:
Summary
We wanted to compare the relation of two different psychophysiological paradigms (PrePulse
Inhibition of the startle response = PPI and P50 suppression) to each other. Additionally, we
wanted to test the effect of the combined serotonin- and noradrenaline re-uptake inhibitor,
imipramine, on these measures. The primary hypothesis was that PPI and P50 gating would not
correlate with each other at baseline. The secondary hypothesis was that increased
noradrenergic and serotonergic activity would disrupt PPI as well as P50 gating.
Phase:
N/A
Details
Lead Sponsor:
Birte Glenthoj
Collaborators:
Glostrup University Hospital, Copenhagen Lundbeck Foundation The Danish Medical Research Council University of Copenhagen