The Effect of Iloprost on Capillary Recruitment and Insulin Sensitivity in Type 2 Diabetes

• Status: Completed
• Trial end date: 2017-06-29
• Target enrollment: 0
• Participant gender: All

Summary

This study examines the effects of iloprost - a stable prostacyclin analogue - on insulin-mediated muscle capillary recruitment and whole-body glucose uptake in a cross-over design.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: VU University Medical Center
• Treatments: Iloprost

Criteria

Inclusion Criteria:

• Type 2 diabetes

• Male or female (post-menopausal)

• Age above 45 years and below 70 years

• BMI >30 kg/m2

• HbA1c < 80 mmol/mol or < 8,6% Subjects must use metformin

• Stable medication use

• Stable tension regulation (with or without medication)

• Subjects should be able to give informed consent

Exclusion Criteria:

• A history of cardiovascular event (Cerebrovascular event, myocardial infarction or pacemaker implantation)

• Severe-very severe lung emphysema (GOLD stage III-IV)

• Use of any antibiotics or proton pump inhibitor (PPI) in the past three months

• Use of any other antidiabetic medication besides metformin (e.g. SU-derivates, insulin)

• Use of a platelet inhibitor or cumarin derivate during

• Subjects participated in a lifestyle programme in the past 6 months (diet or exercise)