The Effect of Ibuprofen on Intrauterine Contraceptive Device Associated Uterine Bleeding
Status:
Completed
Trial end date:
2016-11-01
Target enrollment:
Participant gender:
Summary
The Copper intrauterine device is the most common method of reversible contraception
worldwide. Abnormal uterine bleeding and pain are the most common medical indications for the
discontinuation of the intrauterine device.
Excessive prostaglandin release in the endometrial cavity appears to play an important role
in both bleeding and pain related to copper intrauterine devices.There are many types of
prostaglandin metabolites that present in the endometrium one of them is prostacyclin which
causes vasodilatation and inhibits platelet aggregation. Another one is thromboxane which has
two types; A2 which is active and rapidly converted into B2, which is inactive. Thromboxane
causes vasoconstriction and blood clotting.
Non-steroidal anti-inflammatory drugs (NSAIDs) are prostaglandin synthetase inhibitors acting
by decreasing production of endometrial prostaglandins; they can improve both heavy uterine
bleeding and pain. Since its discovery; several drugs in NSAIDs class have been used to treat
heavy uterine bleeding and pain associated with copper intrauterine device use such as
mefenamic acid, ibuprofen and naproxen.
The most recent systematic review found NSAIDs is the most widely studied drugs for reduction
of the menstrual blood and pain associated with copper intrauterine device. The Cochrane
Review also found that NSAIDs are the most effective treatment to reduce the bleeding with
copper intrauterine device use.