The Effect of IV Amantadine on Freezing of Gait (FOG) Resistant to Dopaminergic Therapy

• Status: Unknown status
• Trial end date: 2011-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Tp determine the effect of IV amantadine on dopaminergic-drug-resistant freezing of gait(FOG)in patients with Parkinson's disease

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul National University Hospital
• Treatments: Amantadine; Dopamine; Dopamine Agents; Dopamine Agonists

Criteria

Inclusion Criteria

• age: 30-80 years

• idiopathic Parkinson's disease

• The patient must be taking optimised levodopa/DDI therapy (based on investigator's judgement) during OPD observation period, though the patient have FOG-Q score ≥ 10 points even though On-state.

Exclusion Criteria:

• "Off" freezing:The patient has improved FOG in "On" state

• clinically significant or unstable medical or surgical condition

• The patient has Parkinson plus like MSA, PSP, and PPFG, and secondary parkinsonism like NPH, vascular parkinsonism, postencephalitic parkinsonism, CO poisoning.

• history of seizure.