The Effect of Hyperbaric Oxygen Therapy on Inflammatory Parameters Induced by a Heat Injury Model

• Status: Completed
• Trial end date: 2015-05-01
• Target enrollment: 0
• Participant gender: Male

Summary

Hyperbaric oxygen may reduce neurophatic pain and promote wound healing. Established anti inflammatory effects of HBO may contribute to this effect. In a previous publication the investigators studied the effects of HBO on secondary hyperalgesia using a well established heat injury model. In a new - blinded study design, the investigators wish to investigate and- or confirm previous results, i.e. that HBO therapy reduce secondary hyperalgesia and improving therapy of severe pain conditions.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Rigshospitalet, Denmark

Criteria

Inclusion Criteria:

• male

• speaks and understands danish language

• understood and signed informed consent before medical examination

Exclusion Criteria:

• younger than 18 years of age

• hypertension

• not able to perform equalization of ears and sinuses

• persons who present with a medical history of previous pneumothorax and/- or who may be considered of increased risk of pneumothorax

• diabetics, epilepsia,asthma

• neurological deficits including cognitive as well as psychomotoric disorders

• claustrophobia