The Effect of Hormonal Contraceptives on Androgens and Glucose Metabolism

• Status: Completed
• Trial end date: 2011-01-01
• Target enrollment: 0
• Participant gender: Female

Summary

The impact of different administration routes of hormonal contraceptives on androgen secretion, glucose metabolism and inflammation. A prospective randomized trial.

The investigators assume, that transdermal or transvaginal hormonal contraception would have less effects on androgen levels, glucose metabolism and inflammatory markers than oral contraceptives.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Oulu
• Treatments: Androgens; Contraceptive Agents; Desogestrel; Estradiol; Estradiol 17 beta-cypionate; Estradiol 3-benzoate; Estradiol valerate; Ethinyl Estradiol; Etonogestrel; Norelgestromin; Norgestrel; NuvaRing; Polyestradiol phosphate

Criteria

Inclusion Criteria:

• healthy women aged from 20 to 35 years

• regular menstruation

• no use of hormonal contraception or two months wash-out period

• no contraindications for using hormonal contraception

Exclusion Criteria:

• irregular menstruation

• smoking

• alcohol addiction

• pregnancy or nursing

• hypersensitivity to any components of the products

• headaches with focal neurological symptoms

• serious or multiple risk factors for artery disease

• undiagnosed abnormal genital bleeding

• impaired glucose tolerance or DM-T2