The Effect of HFA - Beclomethasone Dipropionate Qvar on Bronchial Hyperreactivity in Preschool Children
Status:
Completed
Trial end date:
2010-03-01
Target enrollment:
Participant gender:
Summary
Respiratory diseases including Asthma are high prevalent among preschool children. Specific
treatment, nowadays, include steroid inhalers and anti leukotrienes. It is known that the
amount of the drug reaching small airways and lungs is bigger how much smaller the particles
liberated by inhalers. Beclometasone is being used for treating asthma for 30 years. Lately
emerged a new presentation of beclometasone, which liberates particles as small as 2.1 µg,
that is supposed to reach the small airways at higher concentrations and be more suitable to
patients who don't cooperate properly to the procedure of inhalation.
The investigators' group has reported successfully the possibility to perform Pulmonary
Challenge tests (adenosine, methacholine and exercise) in tender age. Other studies reported
relation between asthma control and reduction in airway hyperreactivity. The purpose of this
study is to evaluate the efficacy of Beclometasone dipropionate - Qvar to reduce airways
hyperreactivity in preschool children, as demonstrated by adenosine challenge test.
Phase:
Phase 2
Details
Lead Sponsor:
Rambam Health Care Campus
Collaborators:
Teva Branded Pharmaceutical Products R&D, Inc. Teva Pharmaceutical Industries