The Effect of Gabapentin on Spinal Anesthesia Duration

• Status: Recruiting
• Trial end date: 2023-01-15
• Target enrollment: 0
• Participant gender: All

Summary

This prospective parallel group double blinded randomized study will be conducted over 50 adult participants between 20 and 60 years ASA (American Association of Anesthesiologists) I and II. The participants will be randomly allocated in 2 groups. Group A will receive 900 mg of gabapentin before surgery in 2 divided doses; 300 mg 10 hours prior to surgery and 600 mg 2 hours before surgery, while group B will receive 2 placebo tablets at the same time. The participants will receive spinal anesthesia in the form of 3ml of hyperbaric bupivacaine 0.5%. Hemodynamics will be recorded every 15 minutes till the end of surgery. Sensory, and motor block progression, and regression will be recorded also.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University
• Treatments: Gabapentin

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists class I, and II

• Age 20 - 60 years

• Weight between 60 and 80 kilograms

• Height between 160 and 180 centimetres

Exclusion Criteria:

• Participants with contraindications to spinal anesthesia.

• Participant refusal

• Extreme short or tall statures

• Body mass index above 40