The Effect of Etomidate on Patient Outcomes After Single Bolus Doses
Status:
Completed
Trial end date:
2010-12-01
Target enrollment:
Participant gender:
Summary
The primary aim is to determine the difference in hospital length of stay between septic
patients given etomidate and those given midazolam for induction during rapid sequence
intubation (RSI) in the emergency department. To achieve this aim we plan to perform a
prospective randomized trial measuring the length of stay of patients meeting sepsis criteria
and requiring intubation. The investigators will compare in-hospital mortality rates between
patients given etomidate and patients given midazolam for induction. In addition to hospital
length of stay, secondary endpoints between the two groups will include length of stay in the
intensive care unit, death within 48 hours of admission, and total number of days intubated.
Research Hypothesis:
In adult patients presenting to the emergency department with sepsis and requiring rapid
sequence intubation, the length of stay of patients given etomidate will be greater than that
of patients given the alternative agent midazolam for induction.