In a randomized study the investigators aim to characterize the effect of antidepressive
medicine on quality of life, body composition, adrenal activity and glucose metabolism in
PCOS.
PCOS is a common endocrine disorder characterized by adrenal and ovarian hyperandrogenaemia,
anovulation and insulin resistance. The pathogenesis of PCOS may be described by a vicious
cycle involving insulin resistance which stimulates ovarian and adrenal hyper androgenaemia
and leads to abdominal obesity, causing increased risk for diabetes and cardiovascular
disease. Adrenal hyperactivity is associated with depression. Antidepressive medicine may
normalize pituitary-adrenal activity and in animal studies antidepressive medicine improved
adrenal hyperactivity and normalized insulin sensitivity.