The Effect of Entecavir Consolidation on Post-TDF Treatment Durability
Status:
Not yet recruiting
Trial end date:
2022-04-30
Target enrollment:
Participant gender:
Summary
Clinical relapse occurred much earlier and tended to be more severe after cessation of TDF
than ETV. The follow-up interval and intensity would be different between ETV and TDF after
discontinuation of therapy. Whether switch therapy from TDF to ETV can modify the pattern of
relapse is interesting but unclear. Our hypothesis is that entecavir consolidation on
post-TDF treatment patients reduce and delay the clinical relapse effectively. Hence in this
proof of concept study we would like to evaluate the effect of 6 months and 12 months of
entecavir consolidation on post-TDF treatment durability.
Phase:
Phase 4
Details
Lead Sponsor:
Taipei Veterans General Hospital, Taiwan
Collaborators:
Chang Gung Memorial Hospital Changhua Christian Hospital China Medical University Hospital