The Effect of Enalapril, Losartan or Not Antihypertensive on the Oxidative Status in Renal Transplant Recipients
Status:
Completed
Trial end date:
2022-01-06
Target enrollment:
Participant gender:
Summary
The clinical and biochemical improvement observed in kidney transplant (RT) recipients is
remarkable. The correct functioning of the allograft depends on various factors such as the
donor's age, the alloimmune response, the ischemia-reperfusion injury, arterial hypertension,
and the interstitial fibrosis of the allograft, among others. Antihypertensive drugs are
necessary for arterial hypertension patients to avoid or reduce the probability of affecting
graft function in RT recipients. Oxidative stress (OS) is another complex pathophysiological
process with the ability to alter post-transplant kidney function. The study's objective was
to determine the effect of the administration of Enalapril, Losartan, or not antihypertensive
medication on the oxidative state in RT recipients at the beginning of the study and one year
of follow-up.
Phase:
Phase 2
Details
Lead Sponsor:
Unidad de Investigacion Medica en Enfermedades Renales