The Effect of Early Use of Methylene Blue on Hemodynamics in Septic Shock
Status:
Active, not recruiting
Trial end date:
2024-01-01
Target enrollment:
Participant gender:
Summary
This study will include patients requiring high dose of norepinephrine (NA) to maintain blood
pressure after fluid resuscitation. The patients will be randomized into two groups, the
study protocol is early combined application of methylene blue. The primary outcome is
Sequential Organ Failure Assessment (SOFA) score 72 hours after admission. Second outcome
includes duration of shock, length of intensive care unit (ICU) hospitalization and so on. To
explore the underlying mechanism, the changes of sublingual microcirculation before and after
vasopressor combination will be collected, also is the global longitudinal strain of left
ventricle.