The Effect of Early Use of Methylene Blue on Hemodynamics in Septic Shock

• Status: Active, not recruiting
• Trial end date: 2024-01-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will include patients requiring high dose of norepinephrine (NA) to maintain blood pressure after fluid resuscitation. The patients will be randomized into two groups, the study protocol is early combined application of methylene blue. The primary outcome is Sequential Organ Failure Assessment (SOFA) score 72 hours after admission. Second outcome includes duration of shock, length of intensive care unit (ICU) hospitalization and so on. To explore the underlying mechanism, the changes of sublingual microcirculation before and after vasopressor combination will be collected, also is the global longitudinal strain of left ventricle.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Xiangya Hospital of Central South University
• Treatments: Methylene Blue

Criteria

Inclusion Criteria:

• Septic shock, receive 0.5 ug/kg/min NA to maintain blood pressure for more than 2 hours after fluid resuscitation.

Exclusion Criteria:

• Pregnant women

• Without internal jugular vein or subclavian vein catheterization

• Child-Pugh grade C with liver cirrhosis

• Severe chronic obstructive pulmonary disease (severe acidosis caused by type II respiratory failure, PaCO2 ≥60mmHg and PH<7.2 )

• End-stage of malignant tumors

• Glucose-6-phosphate dehydrogenase (G6PD enzyme) deficiency

• Positive end-respiratory pressure (PEEP) >10mmHg, the oxygenation index <150mmHg under mechanical ventilation

• Definitive pulmonary hypertension or chronic pulmonary heart disease.

• Oral use of 5-hydroxytryptamine in recent 3 months