The Effect of Dronabinol on the Acquisition and Consolidation of Trauma-Associated Memories

• Status: Recruiting
• Trial end date: 2023-08-31
• Target enrollment: 0
• Participant gender: Female

Summary

The aim of the current project is to investigate the impact of an activation of the cannabinoid system with an exogenous cannabinoid dronabinol (delta-9-tetrahydrocannabinol) on the formation of intrusive memories after analog trauma.

A well-established stress-film paradigm will be used to induce intrusive symptoms in healthy participants. In a double-blind placebo-controlled study, the impact of exogenous dronabinol on intrusive symptoms during exposure to a trauma film will be examined. The primary hypothesis is that exogenous oral dronabinol will decrease the number of intrusive memories recorded in the four days following experimental trauma compared with placebo controls.

This project will contribute to the current understanding of intrusive memory formation in PTSD and may guide the development of future pharmacological preventions.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Charite University, Berlin, Germany
• Treatments: Dronabinol

Criteria

Inclusion Criteria:

• healthy female volunteers

• German on a native level

Exclusion Criteria:

• former or present disorder according to the Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5)

• any physical illnesses

• any medication intake (except oral contraceptive)

• history of traumatic experience, e.g. history of sexual abuse or rape

• pregnancy or lactation period

• follicular phase of menstrual cycle for all women not using oral contraceptives