Overview

The Effect of Doxapram Versus Theophylline on Diaphragmatic Function

Status:
Unknown status
Trial end date:
2019-12-01
Target enrollment:
0
Participant gender:
All
Summary
Doxapram is licensed for drug-induced post-anesthesia respiratory depression , arousal effect and return airway protective reflexes caused by barbiturates, volatile anesthetics, nitrous oxide or benzodiazepines over dosage. Value of theophylline to stimulate the respiratory neuronal network has been examined by previous studies and increases the activity of respiratory muscles, including the intercostal , transversus abdominis muscles and the diaphragm, it also has bronchodilator and anti-inflammatory effects.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Beni-Suef University
Treatments:
Doxapram
Theophylline
Criteria
Inclusion Criteria: Patients (males and females) in the age group 20 -60 scheduled for
elective open heart surgery ( e.g. coronary artery bypass grafting, valve replacement )
under cardiopulmonary bypass .

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Exclusion Criteria:The preoperative exclusion criteria:

1. Age older than 60 years

2. Preoperative left ventricular ejection fraction less than 30%

3. Chronic obstructive pulmonary disease

4. Significant hepatic disease (alanine aminotransferase or aspartate aminotransferase
>150 U/l).

5. Renal failure (creatinine >200 μm).

6. History of seizure, or stroke.

7. History of diaphragmatic palsy, cervical spine injury, or neuromuscular disease (eg,
myasthenia gravis, Guillain-Barré syndrome).

8. Lesion adjacent to the diaphragm

9. Intra-abdominal hypertension (intra-abdominal pressure ≥12 mm Hg )

10. Known allergy to the study drugs.

The Post enrollment exclusion criteria:

1. Postoperative hemorrhage (chest tube drainage ≥ 200 ml/h).

2. Surgical complications necessitating reoperation.

3. Postoperative cardiac failure necessitating high-dose inotropes or intra -aortic
balloon pump.

4. Refractory hypoxemia (ratio of arterial oxygen tension [PaO2] to fraction of inspired
oxygen [FIO2] <150 mmHg).

5. Occurrence of neurologic deficit.

6. -Myocardial ischemia (ST-segment depression) lasting more than 30 min

7. Failure of spontaneous breathing trial.

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