The Effect of Dopamine on Pulmonary Diffusion and Capillary Blood Volume During Exercise

• Status: Recruiting
• Trial end date: 2021-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to examine the effect of dopamine infusion and dopamine-2 receptor blockade on pulmonary capillary blood volume, diffusion, and the hemodynamic variables of pulmonary artery pressure, cardiac output, and pulmonary vascular resistance during exercise. Secondarily, this study will examine the effect of dopamine infusion and dopamine-2 receptor blockade on exercise tolerance.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Alberta
• Collaborator: Natural Sciences and Engineering Research Council, Canada
• Treatments: Dopamine; Dopamine Agents; Metoclopramide

Criteria

Inclusion Criteria:

• Physically active (exercising >2 times per week)

• BMI < 30kg/m2

• No known cardiac or pulmonary disease

Exclusion Criteria:

• Known cardiac or pulmonary diseases / abnormalities

• Use of medications that could interfere with dopaminergic pathways (i.e. dopaminergic agonists / antagonists, alcohol, central nervous system depressants, and serotonergic drugs)

• BMI > 30kg/m2

• Female subjects must not be pregnant