The Effect of Donepezil on Sedation and Other Symptoms
Status:
Terminated
Trial end date:
2007-07-01
Target enrollment:
Participant gender:
Summary
Primary Objective:
1. To determine the effectiveness of donepezil as compared to placebo for the management of
opiate-induced sedation/drowsiness in patients with stable cancer pain
Secondary Objectives:
1. To assess the side-effects in both groups of 1 week treatment of 5 mg donepezil and
placebo
2. To assess the effects of donepezil on fatigue (FACIT-Fatigue), and other symptoms
(Anderson Symptom Assessment Scale)
3. To assess the effects of donepezil on cognition (Symbol Digit Modalities Test)
4. To assess the effects of donepezil on constipation (number of bowel movements)