The Effect of Dexmedetomidine on Propofol Requirement for Insertion of Laryngeal Mask Airway

• Status: Completed
• Trial end date: 2016-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Propofol frequently used as an inducting medication for insertion Laryngeal mask airway(LMA). But propofol alone can be not sufficient for inhibiting upper airway reflex and also result in cardiovascular suppression under enough amount. Dexmedetomidine is a selective alplh2 receptor agonist with analgesic and sedative effects but sparing respiratory function. Therefore propofol combined with dexmedetomidine induction could be more effective in preserve respiration under same condition for LMA insertion than propofol alone. In this study, the investigators investigate the clinical dose of propofol for LMA insertion with premedication of dexmedetomidine, and evaluate the effect of dexmedetomidine.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ajou University School of Medicine
• Treatments: Dexmedetomidine; Propofol

Criteria

Inclusion Criteria:

• patients for surgery not exceed more than 2 hours requiring general anesthesia

Exclusion Criteria:

• history of gastroesophageal reflux High grade obesity Predicted diffiicult airway