The Effect of Dexmedetomidine on Neuroendocrine Stress Hormone Release and Heart Rate Variability in Patients Undergoing Major Spinal Surgery

• Status: Completed
• Trial end date: 2017-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Surgical stress induces stress hormone release and sympathetic hyperactivation. Dexmedetomidine has sympatholytic effect and attenuates stress responses. This study investigate the effect of dexmedetomidine on stress responses and autonomic nervous system balance in patients undergoing major spine surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yonsei University
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

• patient between 20 and 70 of age with ASA physical status Ⅰ-Ⅲ

• patient scheduled for major spine surgery

Exclusion Criteria:

• ASA physical status Ⅳ

• congestive heart failure

• severe hepatorenal disease

• insulin dependent DM(diabetes mellitus)

• cancer or metastasis

• pregnancy

• problem with communication