The Effect of Desflurane Versus Sevoflurane on Postoperative Recovery
Status:
Not yet recruiting
Trial end date:
2024-09-30
Target enrollment:
Participant gender:
Summary
Patients over the age of 65 years are at increased risk for developing delirium and cognitive
complications in the immediate postoperative period after noncardiac surgeries, resulting in
increased morbidity and mortality. Previous small studies have shown beneficial effects of
desflurane on postoperative cognitive recovery, which has been explained by the more rapid
onset and offset of anesthesia as compared to sevoflurane. However, there are very limited
data on the effect of desflurane on postoperative recovery and time until criteria for
discharge from post-anesthesia care unit (PACU) are fulfilled in elderly patients undergoing
minor-to moderate-risk noncardiac surgery. Therefore, we will test our primary hypothesis
that general anesthesia with desflurane significantly reduces the time between
discontinuation of volatile anesthetics after the end of surgery and reaching ready for
discharge from PACU criteria, which are defined as reaching amodified Aldrete score ≥ 12, as
compared to sevoflurane in patients ≥ 65 years of age undergoing minor-to moderate-risk
noncardiac surgery.