The Effect of Deep Versus Moderate Muscle Relaxants in Men During and After Robotic Surgery for Prostate Cancer

• Status: Recruiting
• Trial end date: 2022-01-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to determine if there is a difference in intra-abdominal pressure which surgeons use during surgery and post-surgery pain in men who undergo robotic prostate surgery with deep neuromuscular blockade (NMB), compared with moderate NMB.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Memorial Sloan Kettering Cancer Center
• Treatments: Rocuronium

Criteria

Inclusion Criteria:

• Adult patients under the age of 80

• American Society of Anesthesiologists Physical Status 1, 2, 3.

• Elective Robotic Prostatectomy

• Patient undergoing surgery at Josie Robertson Surgical Center

Exclusion Criteria:

• Age younger than 18

• Inability to provide informed consent

• Allergy to rocuronium, sugammadex, midazolam, propofol, fentanyl, lidocaine, mannitol (IV Acetaeminophen), IV Acetaminophen, Ketorolac, Morphine, Hydromorphone, Dexamethasone, Zofran, Benadryl, Compazine

• Neuromuscular disease

• Any patient with previous abdominal surgery less than or equal to 20 years prior to scheduled surgery date

• Patients with BMI>35

• Severe renal impairment (Creatinine clearance < 30 ml/min)

• Patient receiving Toremifene or any history of receiving Toremifene

• Chronic pain patients

• Patients receiving suboxone

• Patients receiving succinylcholine